Google DeepMind

AlphaGenome 2

Research

Cell-conditional DNA model announced Nov. 11, 2026. It predicts effects for one tissue, cell type, or cell state at a time, including gene expression, chromatin accessibility, histone modifications, and DNA methylation. DeepMind says it identified 30 percent of causal variants on the TenK10K immune-cell set, versus 16 percent for the prior model fine-tuned on single-cell data, after training on more than 107 million cell profiles. Available for non-commercial research through the AlphaGenome API and in private preview for commercial research. Not validated for clinical or diagnostic use.

Latest update Nov 12, 2026

  1. DeepMind releases AlphaGenome 2 for cell-specific DNA effects

    Google DeepMind said on Nov. 11 that AlphaGenome 2 predicts how a DNA sequence and its variants affect one cell type or cell state at a time, instead of averaging across a tissue. The lab said the model, trained on more than 107 million individual cell profiles, identified 30 percent of causal variants in the TenK10K immune-cell set, compared with 16 percent for the prior model fine-tuned on single-cell data. It is available for non-commercial research through the AlphaGenome API, with a private preview for commercial research, and DeepMind says it is not validated for clinical or diagnostic use.

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